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Figure 23.10 Carcinoma of the penis. Diagrammatic representation of flat-ulcerating (A) and cauliflower papillary (B) patterns of growth at
common locations. C, Amputated specimen of the penis shows a cauliflower growth on the coronal sulcus (arrow). The surface of the growth is
ulcerated and is chalky-white in appearance.

Grossly, it appears as a solitary, circumscribed plaque Bowenoid Papulosis
lesion with ulceration. The lesions of bowenoid papulosis appear on the penile shaft
Histologically, the changes are superficial to the dermo- and adjacent genital skin.
epidermal border. The epithelial cells of the epidermis
show hyperplasia, hyperkeratosis, parakeratosis and Grossly, they are solitary or multiple, shiny, red-brown
scattered bizarre dyskeratotic cells. papular lesions.
Histologically, there is orderly maturation of epithelial
A fair proportion of cases of Bowen’s disease are cells in hyperplastic epidermis with scattered hyper- CHAPTER 23
associated with internal visceral cancers. chromatic nuclei and dysplastic cells.

Erythroplasia of Queyrat
MALIGNANT TUMOURS
The lesions of erythroplasia of Queyrat appear on the penile
mucosa. Squamous Cell Carcinoma

Grossly, the lesions are pink, shiny and velvety soft. The incidence of penile carcinoma shows wide variation in
Histologically, the thickened and acanthotic epidermis different populations. In the United States, the overall
shows variable degree of dysplasia. incidence of penile cancer is less than 1% of all cancers in
Unlike Bowen’s disease, there is no relationship males but it is 3-4 times more common in blacks than in
between erythroplasia of Queyrat and internal whites. In some Asian, African and Latin American countries,
malignancy. its incidence is about 10% of all cancers. Relationship of
penile cancer with HPV has been well supported; high-risk The Male Reproductive System and Prostate

Figure 23.11 Squamous cell carcinoma penis. Microscopy shows whorls of malignant squamous cells with central keratin pearls.