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92     Chapter 4


                                            Initial Settings


                                            The BiPAP system may be used in one of three modes: spontaneous, spontaneous/
                          The initial settings of   timed, and timed. Mode selection depends on a patient’s needs and ability to breath
                        IPAP and EPAP are 8 cm H 2 O
                        and 4 cm H 2 O, respectively.  spontaneously. In general, if the patient is breathing spontaneously, the IPAP and EPAP
                                            may be initially set at 8 cm H O and 4 cm H O, respectively (ResMed, 1998a,b). The
                                                                    2
                                                                                 2
                                            pressures are titrated based on needs, generally with a target of 5 to 7 mL/kg. Refer to
                                            Table 7-7 for titration of bilevel positive airway pressure. The spontaneous/timed mode
                                            is used as a backup mechanism and the frequency per min (f/min) is set two to five
                                            breaths below the patient’s spontaneous frequency. In the timed mode, set IPAP and
                                            EPAP as above and the f/min slightly higher than the patient’s spontaneous frequency.
                                            The % IPAP may be set at 33% or 50% for an I:E ratio of 1:2 or 1:1, respectively.

                                            Adjustments of IPAP and EPAP


                                            IPAP levels are generally determined by monitoring the patient’s clinical and physi-
                                            ologic response to gradual changes of IPAP, rather than by directly measuring the
                                            volume delivered.
                                             When the cardiopulmonary responses are positive, the IPAP may be increased in
                          IPAP may be increased in   increments of 2 cm H O to enhance the “pressure boost” to improve ventilation, nor-
                        increments of 2 cm H 2 O to en-       2
                        hance the “pressure boost” to   malize PaCO , and reduce the work of breathing. Since IPAP does not provide volume-
                                                      2
                        improve alveolar ventilation,   controlled ventilation, the volume delivered by IPAP is directly related to the IPAP and
                        normalize PaCO 2 , and reduce
                        the work of breathing.  EPAP pressure gradient and the compliance characteristics of the lung/thorax system.
                                            The volume delivered is inversely related to the airflow resistance. In other words, a
                                            larger delivered volume may be obtained by (1) increasing the IPAP level, (2) decreasing
                                            the EPAP level, (3) increasing the compliance, and (4) reducing the airflow resistance.
                                             The EPAP should be increased by 2 cm H O increments to increase functional
                                                                                  2
                          The EPAP should be   residual capacity and oxygenation in patients with intrapulmonary shunting. When
                        increased by 2 cm H 2 O
                        increments to increase func-  the EPAP is the same as the IPAP, CPAP results. It is not possible to increase the
                        tional residual capacity and   EPAP higher than the IPAP. Since IPAP and EPAP are methods to manipulate the
                        oxygenation in patients with
                        intrapulmonary shunting.   airway pressures, all adverse effects of positive pressure ventilation and PEEP should
                                            be monitored. The patient should be advised to report any unusual chest discom-
                                            fort, shortness of breath, or severe headache when using the BiPAP system.
                                             There are other similar modes that provide two CPAP or pressure levels (high
                           A BiPAP device can be   pressure and low pressure), and the patient is allowed to breathe spontaneously
                        used as a CPAP device by set-
                        ting the IPAP and EPAP at the   without restriction. See airway pressure release ventilation (APRV) and biphasic
                        same level.         positive positive airway pressure (biphasic PAP) in this chapter for details.


                      CONTROLLED MANDATORY VENTILATION (CMV)



                                            With controlled mandatory ventilation (CMV), also known as continuous manda-
                      control mode: In control mode,
                      the ventilator delivers the preset   tory ventilation or control mode, the ventilator delivers the preset tidal volume at a
                      tidal volume at a set time interval   time-triggered frequency (Figure 4-4). Since the ventilator controls both the patient’s
                      (time-triggered frequency).
                                            tidal volume and respiratory frequency, the ventilator “controls” the patient’s minute






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