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Monitoring in Mechanical Ventilation  261


                                             Capnography


                                             Capnography is a measurement of the partial pressure of carbon dioxide in a
                                             gas sample. When the sample is collected at the end of expiration, it is called
                                             end-tidal partial pressure of carbon dioxide (PetCO ). PetCO  monitoring pro-
                                                                                                    2
                                                                                           2
                                             vides real-time, noninvasive analysis of a patient’s expired CO  trend during
                                                                                                       2
                                             mechanical ventilation. Ventilators have built-in end-tidal CO  monitoring ca-
                                                                                                     2
                                             pabilities.
                                               The exhaled CO  from the patient ventilator circuit is collected and measured by
                                                             2
                                             the infrared absorption technique (Hess, 1990). A mainstream sensor is placed di-
                                             rectly onto the ventilator circuit, usually attached to an adaptor on the endotracheal
                                             tube. A sidestream sensor aspirates a sample of gas via a small tube connected to the
                                             endotracheal tube adaptor. Figure 9-12 illustrates the mainstream and sidestream
                                             capnography sensors.
                                               The major advantage of mainstream analysis is the fast response time between
                                             actual CO  sampling and the display update. The disadvantage of the mainstream
                                                      2
                                             adaptor is its excessive weight on the endotracheal tube as well as the additional
                                             deadspace in the ventilator/patient circuit. With mainstream sampling, water con-
                                             densation does not affect analysis; however, secretion buildup on the cell windows
                                             can affect the accuracy. A mainstream analyzer also tends to be more frequently
                                             handled than the sidestream sensor because the clinician must disconnect it manu-
                                             ally to suction the patient (Shelley, 1989).
                                               A sidestream analyzer (aspirating analyzer) places the analyzing mechanism
                                             safely within the monitor and draws a sample via a tube connected at the pa-
                                             tient’s airway (e.g., endotracheal tube). The major advantage with sidestream
                                             analysis is the ease of handling, and the analyzer can be attached to other pa-
                                             tient devices (e.g., cannula, mask). The major disadvantage is that with peri-
                                             odic aspiration of air samples, secretions and water can be drawn into the sam-
                                             pling tube and cause an occlusion. Lag time for CO  display is slightly longer
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                                             (a few tenths of a second) than the mainstream analyzer but it is negligible.
                                             Equipment  contamination  may  be  a  problem  with  the  sidestream  analyzer
                                             (Shelley, 1989).

                                             Capnography Waveforms and
                                             Clinical Application


                                             A capnogram (Figure 9-13) shows the changes in P CO  during a complete respi-
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                                                                                         E
                                             ratory cycle. The P CO  is at zero before exhalation. At the beginning of exhala-
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                                                              E
                                             tion, the P CO  remains at zero as anatomic deadspace volume exits the airways
                                                       E
                                                           2
                                             (phase I). The P CO  then increases dramatically as alveolar gas begins mixing
                                                                2
                                                            E
                                             with deadspace gas (phase II). Then the curve plateaus, reflecting the exhalation
                                             of alveolar gas (phase III). The end of the “alveolar plateau” is called the end-tidal
                            The PetCO 2  may be used
                          to estimate the PaCO 2 .  PCO  (PetCO ). Since the PetCO  approximates the alveolar PCO , this value may
                                                                                                      2
                                                  2
                                                          2
                                                                          2
                                             be used to estimate the PaCO .
                                                                       2
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