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                                                                           CHAPTER 1 / Cardiac Anatomy and Physiology   9

                     working atrial myocardial cells, the penetrating AV bundle, and  goes inferiorly and posteriorly across the left ventricular inflow
                     the branching AV bundle. 19,20                      tract to the base of the posterior papillary muscle; it then spreads
                       Fibers from the AV node converge into a shaft termed the bun-  diffusely through the posterior inferior left ventricular free wall. It
                     dle of His (also called the penetrating AV bundle or common bun-  is approximately 20 mm long and 6 mm thick. This fascicle is of-
                     dle). It is approximately 10 mm long and 2 mm in diameter. 18  ten the least vulnerable segment of the ventricular conducting sys-
                     The bundle of His passes from the lower right atrial wall anteri-  tem because of its diffuseness, its location in a relatively protected
                     orly and laterally through the central fibrous body, which is part  nonturbulent portion of the ventricle, and its dual blood supply
                     of the fibrous skeleton.                             (Table 1-1).
                        As first noted by His in 1893, 21  the His bundle provides the  Three, rather than two, major divisions of the left bundle
                     only cellular connection between the atria and ventricles and is of  branch are sometimes found, with a group of fibers ramifying
                     pivotal functional importance. Cardiac impulse transmission is  from the left posterior fascicle and terminating in the lower sep-
                                                                                                20
                     slowed at this site, providing time for atrial contraction to dispel  tum and apical ventricular wall. This trifascicular configuration
                     blood from the atria into the ventricles. This slowing boosts ven-  of the bundles explains some conduction defects involving partial
                     tricular volume and increases the cardiac output during subse-  bundle-branch block. Sometimes instead of three discrete bundles
                     quent ventricular contraction. At the membranous septal region  the common left bundle fans out diffusely along the septum and
                     of the heart, the right atrium and left ventricle are opposite each  the free ventricular wall. 28
                     other across the septum, with the right ventricle in close proxim-  Purkinje fibers, first described in 1845, form a complex net-
                                                       22
                     ity. Three of the four cardiac valves are nearby. Thus, pathology  work of conducting tissue ramifications that provide a continua-
                     of the fibrous skeleton, tricuspid, mitral, or aortic valves can af-  tion of the bundle branches in each ventricle. 29  The Purkinje
                     fect functioning of one or more of the other valves or may affect  fibers course down toward the ventricular apex and then up to-
                     cardiac impulse conduction. Dysfunction of the AV conducting  ward the fibrous rings at the ventricular bases. They spread over
                     tissue may affect the coordinated functioning of the atria and  the subendocardial ventricular surfaces and then spread from the
                     ventricles.                                         endocardium through the myocardium; thus, spreading from in-
                        Abnormal accessory pathways, termed Kent bundles, occasion-  side outward, providing extensive contacts with working myocar-
                     ally join the atria and ventricles through connections outside the  dial cells, and coupling myocardial excitation with muscular con-
                     main AV node and His bundle. 23,24  Tracts from the His bundle to  traction.
                     upper interventricular septum (termed paraspecific fibers of Ma-
                     haim) sometimes occur and are also abnormal. 25,26  AV conduc-
                     tion is accelerated when impulses bypass the delay-producing AV  CORONARY CIRCULATION
                     junction and travel instead through these abnormal connections.
                     When accelerated AV conduction occurs, cardiac output often de-  The heart is continuously active. Like all tissues, it must receive
                     creases because there is inadequate time for atrial contraction to  oxygen and metabolic substrates; carbon dioxide and other
                     boost ventricular filling. 27                        wastes must be removed to maintain aerobic metabolism and
                       The His bundle begins branching in the region of the crest of  contractile activity. However, unlike other tissues, it must gener-
                     the muscular septum (Fig. 1-11). The right bundle branch typi-  ate the force to power its own perfusion. The heart requires con-
                     cally continues as a direct extension of the His bundle. The right  tinuous perfusion.
                     bundle branch is a well-defined, single, slender group of fibers
                     approximately 45 to 50 mm long and 1 mm thick. It initially  Coronary Arteries
                     courses downward along the right side of the interventricular
                     septum, continues through the moderator band of muscular tis-  The major coronary arteries in humans are the right coronary
                     sue near the right ventricular apex, and then continues to the  artery and the left coronary artery, sometimes called the left
                     base of the anterior papillary muscle. If a small segment of the  main coronary artery. These arteries branch from the aorta in the
                     bundle is damaged, the entire distal distribution is affected be-  region of the sinus of Valsalva (Figs. 1-12 and 1-13). They ex-
                     cause of the right bundle’s thinness, length, and relative lack of  tend over the epicardial surface of the heart and branch several
                     arborization.                                       times. The branches usually emerge at right angles from the par-
                       The left bundle branch arises almost perpendicularly from the  ent artery.  30  The arteries plunge inward through the myocardial
                     His bundle as the common left bundle branch. This common left  wall and undergo further branching. The epicardial branches
                     bundle, approximately 10 mm long and 4 to 10 mm wide, then  exit first. The more distal branches supply the endocardial (in-
                     divides into two discrete divisions, the left anterior bundle branch  ternal) myocardium. The arteries continue branching and even-
                     and the left posterior bundle branch. The left anterior bundle  tually become arterioles, then capillaries. Partially because the
                     branch, or left anterior fascicle, is approximately 25 mm long and  blood supply originates more distally, the endocardium is more
                     3 mm thick. It usually arises directly from the common left bun-  vulnerable to compromised blood supply than is the epicardial
                     dle after the origin of the posterior fascicle and close to the origin  surface.
                     of the right bundle. It branches to the anterior septum and courses  There is much individual variation in the pattern of coronary
                     over the left ventricular anterior (superior) wall to the anterior  artery branching. In general, the right coronary artery supplies the
                     papillary muscle, crossing the aortic outflow tract. Anterior and  right atrium and ventricle. The left coronary artery supplies much
                     septal myocardial infarctions and aortic valve dysfunction often  of the left atrium and ventricle. The following discussion describes
                     affect the left anterior bundle branch.             the most common arterial pattern. Table 1-1 lists the major car-
                       The large, thick, left posterior bundle branch, or left posterior  diac structures, their usual arterial supply, and some common
                     fascicle, arises either from the first portion of the common left  variations (e.g., either the right or the left coronary artery may
                     bundle or from the His bundle directly. The left posterior fascicle  supply the AV node).
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