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310  P R I N C I P L E S   A N D   P R A C T I C E   O F   C R I T I C A L   C A R E




                                                                                             Left side battery
                                                                                             omitted for clarity



                                                                                                Aorta


                                                                                                   Heart


                                                             External
                                                              battery
                                                              pack

             A
                                                                                                         XVE
                                                                                                        LVAD


                                                                                 Skin
                                                                                  line
                                                                                        Vent adapter &
                                                                          XVE System      vent filter
                                                              B            controller










                                                      FIGURE 12.12  Mechanical circulatory support VADs: (A) Thoratec®USA LVAD and
                                                      RVAD; (B) HeartMate®USA; (C) VentrAssist ((A) and (B) Courtesy Thoratec Corpora-
                                                      tion (C) Courtesy Ventracor Limited).











             C



         in  patients  over  70  years  of  age  would  be  expected  to   Patients  referred  for  heart  transplant  assessment  must
         exclude  the  majority  of  such  patients  from  consider-  have exhausted all other accepted pharmacological and
         ation. 66,71  Other relative contraindications include renal   surgical  treatment  options  for  end-stage  heart  failure,
         failure and an irreversible high transpulmonary gradient   such  as  optimal  therapeutic  doses  of  common  heart
         (mean  pulmonary  artery  pressure  minus  pulmonary   failure medications; revascularisation via coronary artery
                                                     72
         artery wedge pressure) of greater than 15 mmHg  (see   bypass  graft  surgery  or  percutaneous  transluminal
         section  on  Early  allograft  dysfunction  and  failure  later  in   coronary  angioplasty;  continuous  IV  infusions  of
         this chapter). In the context of a rigorous postoperative   do butamine  in  the  community/home  setting;  IV  levo-
         regimen  of  polypharmacy,  frequent  follow-up  medical   simendan  (a  calcium  sensitiser);  antiarrhythmic  drugs
         appointments  and  routine  cardiac  biopsies,  a  strong   to  suppress,  or  an  internal  cardiac  defibrillator  to
         social  support  network,  absence  of  psychiatric  illnesses   treat,  potentially  lethal  arrhythmias;  and  insertion  of
         and a willingness to participate actively in the recovery   a  biventri cular  pacemaker  (i.e.  chronic  resynchronisa-
         process are highly desirable characteristics of prospective   tion  therapy)  to  re-establish  atrioventricular  synchrony
         recipients. 72                                       (see  Chapter  11).
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