Page 2105 - Hematology_ Basic Principles and Practice ( PDFDrive )

1868 Part XII Hemostasis and Thrombosis

molecule” that collects binding partners and localizes them adjacent the affinity of spectrin for adducin-actin complexes is greater than for
to the plasma membrane. Partners bound by filamin members include either actin or adducin alone. Platelet glycoproteins involved in
the small GTPases, RalA, Rac, Rho, and Cdc42, with RalA binding attaching spectrin to the membrane remain to be defined.
in a GTP-dependent manner; the exchange factors Trio and Toll;
kinases such as PAK1; phosphatases; and transmembrane proteins.
Most partner proteins are bound within the C-terminus portion of
filamin. REFERENCES
Central to the structural organization of the resting platelet is an
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