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836 Part VII Hematologic Malignancies
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A
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Fig. 56.56 COMPLEX KARYOTYPE OF BURKITT LYMPHOMA. Bone marrow karyotype of a patient
diagnosed in an advanced stage of Burkitt lymphoma (A) and after application of the multicolor FISH (B) to
resolve complex derivative chromosomes, showing 46, XY, del(2)(p21p23), t(8;14)(q24;q32), dup(12)
(q13q24.3), der(16)(t(11;16)(p11.2;q24) karyotype. Arrows indicate abnormal chromosomes. In addition to
the classic t(8;14), both duplications of 11q and 12q were identified with multicolor FISH technology.
and germinal center B (GCB)–like DLBCL. According to the WHO of the 6q21–23 region. Patients with GCB DLBCL have frequent
2016 classification, these two subgroups of DLBCL the GCB and gains of the 12q12 chromosomal region. Patients with primary
ABC subgroups differ in their chromosomal alterations activation of mediastinal lymphoma have gains of 2p14–p16 and 9p21-pter.
signaling pathways and clinical outcome. Patients with ABC-DCLBC Apparently, gains in several regions of chromosome 3 are significantly
frequently exhibit trisomy of 3, gains of 3q and 18q21–23, and loss associated with inferior survival. Moreover, genomic gains involving
