Page 955 - Williams Hematology ( PDFDrive )

930 Part VII: Neutrophils, Eosinophils, Basophils, and Mast Cells Chapter 60: Structure and Composition of Neutrophils, Eosinophils, and Basophils 931

TABLE 60–1. Neutrophil Granules
Membrane
Granules Markers NADPH Oxidase Receptors Antimicrobial Enzymes Other Factors
Primary CD63 BPI-protein Elastase Acid mucopoly-
(azurophilic) saccharide
CD68 Defensins (HNP Cathepsin G α -Antitrypsin
1
1–4)
V-type H -ATPase CAP37 Proteinase 3
+
Myeloperoxidase α-Mannosidase
Lysozyme β-Glucuronidase
β-Glycerophos-
phatase
Sialidase
N-Acetyl-β-
glucosaminidase
Secondary CD15 gp91phox Formyl peptide R Lactoferrin Gelatinase B β -Microglobulin
2
(specific) (MMP-9)
CD66 p22phox CR3 (CD11b/ Lysozyme Histaminase Vitamin B -bind-
12
CD18) ing protein
CD67 Rap1A Fibronectin R hCAP-18 Sialidase Plasminogen
activator
CD11b/CD18 Rap2 G-protein Collagenase
α-subunit (MMP-8)
Laminin R Heparinase NGAL (lipocalin)
Thrombospon-
din R
TNF R
uPAR
VAMP-2
Vitronectin R
Tertiary CD11b/CD18 gp91phox Formyl peptide R Lysozyme Gelatinase B β -Microglobulin
2
(MMP-9)
V-type H -ATPase p22phox CR3 (CD11b/ Acetyltransferase Oncostatin M
+
CD18)
Rap1A uPAR Diacylglycerol-
deacylating
enzyme
VAMP-2
Secretory CD11b/CD18 gp91phox Formyl peptide R CAP37 Proteinase 3 Plasma proteins
vesicles (e.g., albumin)
CD10 p22phox CR1 (CD35)
CD13 Rap1A CR3 (CD11b/ Decay accelerat-
CD18) ing factor
CD45 CR4 (CD11c/
CD18)
CD35 C1qR
CD14 FcγRIIIB (CD16)
uPAR
ATPase, adenosine triphosphatase; BPI, bactericidal/permeability-increasing protein; hCAP, human cationic peptide; HNP, human neutrophil
peptide; MMP-9, metalloproteinase-9; NGAL, neutrophil gelatinase-associated lipocalin; TNF, tumor necrosis factor; uPAR, urokinase plasmino-
gen activator receptor, VAMP, vesicle-associated membrane protein.
Data regarding antimicrobial factors from Refs. 15 to 41. Data regarding enzymes from Refs. 42 to 56.

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