Page 393 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPtEr 25 Host Defenses to Viruses 374.e1

MUL t IPLE-CHOICE QUES t IONS

1. Many of the most medically important human viruses are 3. Immunological memory is a cardinal feature of adaptive
associated with persistent viremia, including human immu- immunity to virus infection. Memory T cells can be divided
nodeficiency virus (HIV) and hepatitis C virus (HCV). What into multiple subsets. Which of the following statements
are the effects of high levels of persisting antigen on the accurately describe the major subsets of memory T cells?
immune response? A. Effector memory T cells migrate through lymphoid tissues,
A. Increased killing capacity by cytotoxic T cells central memory T cells migrate through nonlymphoid
B. Altered tissue distribution and impaired functions of T tissues, and tissue-resident memory T cells circulate in
cells blood.
C. Upregulation of T-cell proliferation B. Effector memory T cells migrate through nonlymphoid
D. Enhanced cytokine production by virus-specific T cells tissues, central memory T cells persist in nonlymphoid
E. Reduced expression of coinhibitory molecules by the tissues, and tissue-resident memory T cells persist pre-
responding virus-specific T cells dominantly in lymphoid tissues.
C. Effector memory T cells persist in nonlymphoid tissues
2. Many viral infections can cause immunopathological reactions,
such as herpetic stromal keratitis induced by herpes simplex and do not enter blood, central memory T cells persist in
virus. What is a major parameter in the pathogenesis of this lymphoid tissues, and tissue-resident memory T cells
disease? migrate predominantly through nonlymphoid tissues.
A. Inhibition of inflammatory cell recruitment into the infected D. Effector memory T cells migrate exclusively in blood, central
tissues memory T cells migrate through lymphoid tissues, and
B. Recruitment of cytotoxic CD4 T cells that cause ocular tissue-resident memory T cells are retained in nonlymphoid
pathology tissues.
C. Recruitment and retention of pathogenic CD8 T cells in E. Effector memory T cells migrate through nonlymphoid
the late stage of the response tissues, central memory T cells migrate through lymphoid
D. Recruitment and retention of pathogenic Th1 CD4 T cells tissues, and tissue-resident memory T cells are retained
into the ocular tissues in tissues.
E. Reduction in Th17 CD4 T cells in the ocular tissues