Page 69 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 3 Innate Immunity 53.e1

MULTIPLE-CHOICE QUESTIONS

1. Which of the following statements regarding the complement 3. Which of the following cell types is responsible for mediating
system is true? type 1 hypersensitivity reactions:
A. Defects in early components of the complement cascade A. Dendritic cells
(i.e., C1, C2, or C3) are associated with increased suscep- B. Neutrophils
tibility to meningococcal infections. C. Natural killer T (NKT) cells
B. Paroxysmal nocturnal hemoglobinuria results from muta- D. Mast cells
tions within the CD55 gene. 4. Inflammasome activation leads to release of mature inter-
C. The classical complement pathway is initiated by the leukin-1 (IL-1) and IL-18. Activation of which of the following
spontaneous generation of C3b in the plasma. receptors leads to activation of the inflammasome?
D. Hereditary angioedema results from mutations in the C1 A. Nucleotide-binding oligomerization domain (NOD)-like
esterase inhibitor gene.
receptor–related proteins
2. Which of the following are characteristics of natural killer B. Toll-like receptors (TLRs)
(NK) cells? C. Complement receptors
A. NK cells require two signals to kill targets. D. RIG-I–like receptors
B. NK-cell function is regulated by a balance between inhibit-
ing and activating signals.
C. CD56 bright NK cells have potent cytotoxicity activity.
D. NK cells express somatically rearranged receptors.