Page 783 - Textbook of Pathology, 6th Edition

BCL-2 have low positivity in high-grade in situ ductal 1. routine histopathology criteria; 767
carcinoma and likelihood of recurrences after conservative 2. hormone receptor status; and
surgery. 3. biological indicators.
3. Invasive breast cancer. Prognostic and predictive factors A summary combining all these factors is given in
for invasive breast cancer have been extensively studied by Table 25.3.
univariate analysis (examining single factor separately) as Overall, taking the most important parameter of node-
well as by multivariate analysis (comparing the value of positive or node-negative breast cancer, the prognosis
various factors included in a study). These can be broadly varies— localised form of breast cancer without axillary
divided into 3 groups: lymph node involvement has a survival rate of 84% while
survival rate falls to 56% with nodal metastases.

❑ CHAPTER 25

The Breast