Page 61 - B.Tech Biotech Curriculum and Syllabus R2017 - REC

Department of BIOTECHNOLOGY, REC

UNIT IV TQM TOOLS AND TECHNIQUES II 9
Control Charts - Process Capability - Concepts of Six Sigma - Quality Function Deployment (QFD) -Taguchi
quality loss function - TPM - Concepts, improvement needs - Performance measures. POKA-YOKE.

UNIT V QUALITY SYSTEMS 9
Need for ISO 9000 - ISO 9001:2015 Quality System - Elements, Documentation, Quality Auditing -
QS 9000 - ISO 14000 - Concepts, Requirements and Benefits – ISO 9000:2005, ISO 9004:2009 - TQM
Implementation in manufacturing and service sectors. Quality System for Automotive Supplier TS 16949,
Quality System for Telecom Industries - TL 9000

TOTAL: 45 PERIODS
OUTCOMES:
On the successful completion of the course, students
 Have Ability to explain the importance of quality in engineering.
 Have Ability to explain various principles in TQM.
 Can explore the knowledge of implementing various TQM tools.
 Have Ability to create rapport among workers to form a quality team.
 Have Ability to explain the benefits of implementing ISO-9000 & ISO-14000 in manufacturing and service
sectors.

TEXT BOOK:
1. Dale H. Besterfiled, et at., "Total quality Management", Third Edition, Pearson Education Asia, Indian Reprint,
2011.

REFERENCES:
1. James R. Evans and William M. Lindsay, "The Management and Control of Quality", 8th
2. Edition, First Indian Edition, Cengage Learning, 2012.
3. Suganthi.L and Anand Samuel, "Total Quality Management", Prentice Hall (India) Pvt. Ltd.,
2006.
4. Janakiraman. B and Gopal .R.K., "Total Quality Management - Text and Cases", Prentice Hall (India) Pvt. Ltd.,
2006.

BT17701 DOWNSTREAM PROCESSING L T P C
3 0 0 3

OBJECTIVES:
To enable the students to
 Gain knowledge about the methods to obtain pure proteins, enzymes and in general about product
development R & D. Have depth knowledge and hands on experience with on Downstream processes
required in multi-factorial manufacturing environment in a structured and logical fashion

UNIT I DOWNSTREAM PROCESSING 10
Introduction to downstream processing, principles, characteristics of bio-molecules and bioprocesses.Cell
disruption for product release – mechanical, enzymatic and chemical methods.Pretreatment and stabilisation
of bio-products.

UNIT II PHYSICAL METHODS OF SEPARATION 6
Unit operations for solid-liquid separation - filtration and centrifugation.

UNIT III ISOLATION OF PRODUCTS 12
Adsorption, liquid-liquid extraction, aqueous two-phase extraction, membrane separation – ultrafiltration and
reverse osmosis, dialysis, precipitation of proteins by different methods.

UNIT IV PRODUCT PURIFICATION 12
Curriculum and Syllabus | B.Tech. Biotechnology | R2017 Page 61