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288 SECTION III CARDIOvASCuLAR ``CARdIOvASCulAR—PHYSIOlOGY CARDIOvASCuLAR ``CARdIOvASCulAR—PHYSIOlOGY
Pressure-volume loops and valvular disease
Aortic stenosis 200 LV pressure
LV > aortic ESV
pressure
120
LV pressure (mmHg) 100 Blood pressure (mmHg) 50 No change in EDV
SV
compliance EDP for given EDV
0 0 Ventricular hypertrophy ventricular
100 200
LV volume (ml) Time (RR interval)
Mitral regurgitation 200 120 No true isovolumetric phase
ESV due to resistance and
LV pressure (mmHg) 100 Blood pressure (mmHg) 50 Tall EDV due to LA volume/pressure from
regurgitation into LA during systole
V-wave
regurgitation ventricular filling
0 0 SV
100 200
LV volume (ml) Time (RR interval)
Aortic regurgitation 200 No true isovolumetric phase
EDV
120
Large
LV pressure (mmHg) 100 Blood pressure (mmHg) 50 pressure SV
pulse
0 0
100 200
LV volume (ml) Time (RR interval)
Mitral stenosis 200 LA pressure
EDV because of impaired ventricular
120
LV pressure (mmHg) 100 Blood pressure (mmHg) 50 LA > LV ESV
filling
pressure
SV
0 0
100 200 Time (RR interval)
LV volume (ml)
FAS1_2019_07-Cardio.indd 288 11/7/19 4:24 PM
