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                  470    P A R T  III / Assessment of Heart Disease
                  CVP. An increased CVP is usually an indication of later stages of  CVP is measured at end-diastole, although consideration
                  LV failure, although the CVP may remain normal even in the  must also be given to the effect of the maximal pressure. Useful
                  presence of high PA pressures and pulmonary edema.  clinical information can also  be obtained  by examining the
                                                                      CVP/RAP waveforms. There are five mechanical components (a,
                  Complications                                       c, v waves and x and y descent) of the CVP waveform. A dual-
                                                                      channel strip chart recorder should be used to identify the corre-
                  Complications associated with CVP monitoring include local-  sponding venous pressure waves with the electrical events on the
                  ized infection, arrhythmias, vessel laceration, RV perforation,  ECG (Display 21-3). The mean CVP is determined by bisecting
                  thrombophlebitis, hematoma formation at the insertion site, and  the a, c, and v waves so that there are equal areas above and below
                  pneumothorax or a malpositioned catheter. 134  The most com-  the bisection or measured at the leading edge of the c wave (also
                  mon predictor of complications, particularly pneumothorax, is  known as the “z” point). The z point reflects the final pressure in
                  the number of needle insertions required to access the vein.  the RA just before the onset of RV systole and the closure of the
                  There is an increased risk of arterial puncture, but fewer malpo-  AV valves; thus, this point represents the RV end-diastolic pres-
                  sitioned catheters, with the jugular approach.  134  Conversely,  sure (preload). Alternatively, if the a and c waves cannot be visu-
                  there may be a decreased risk of infection with a subclavian ver-  alized, draw a straight line through the Q wave or the upstroke of
                                                                                                               7
                  sus jugular or femoral insertion. 35,135            the arterial pressure waveform to identify end-diastole. If there
                                                                      are large A and V waves, the CVP measurement should be made at
                  Measurement Technique                               the z point or the base of the a wave if the z point cannot be iden-
                                                                      tified. 142  If there is a large A or V wave, the peak A or V wave pres-
                  The CVP system is referenced by placing the air–fluid interface of  sure indicates increased upstream hydrostatic pressures (e.g., he-
                  the stopcock at the level of the phlebostatic axis (see 
 in Fig. 21-1)  patic, renal). The CVP tracing may be useful in the diagnosis of
                  or at a point 5 cm below the sternal angle. With correct referencing,  wide-complex tachyarrhythmias of unknown origin, tricuspid re-
                  the  hemodynamically stable  patient can  be  positioned up to  gurgitation (large V wave that begins with the onset of systole), re-
                  45 degrees for CVP measurements. 136                striction of RV filling due to ventricular stiffness or volume overload
                     An area of confusion when measuring the CVP from a triple lu-  (y ( descent   4 mm Hg—these patients are not likely to respond
                  men catheter is the question of which port to transduce. There are  with increased CO if given a fluid bolus), 143  pericardial tamponade
                  no research-based recommendations regarding port selection. The  (loss of x and y descent) (Fig. 21-10), and constrictive pericarditis.
                  differences in pressures measured from the various ports are small
                  ( 1.5 mm Hg). 118  When the distal port is used there is limited
                  effect from fluids administered via the more proximal ports. 137  Be-  PA PRESSURE MONITORING
                  cause of the potential for a clinically significant change in pressure
                  depending on the port transduced, it seems prudent to transduce  Indications
                  consistently one port, and if a change in the site of monitoring is
                  necessary, to annotate the change on the flowsheet.  Between 1993 and 2004, the use of PA catheters has decreased
                                                                      65%, 144  with the greatest decrease occurring after the publication
                  Interpretation of CVP Data                          of a study of 5,735 patients in 1996, which suggested that PA
                                                                      catheter use may increase morbidity and mortality. 145  Since this
                  There has been increased use of CVP to guide therapy due to the  study, several consensus conferences 146–148  identified patient pop-
                  decreased use of PA catheters and results of a study in patients  ulations for which PA pressure monitoring may be beneficial or
                  with acute lung injury, which suggests that outcomes from ther-  additional outcome studies are needed and that there is a need for
                  apy guided by central venous catheter measurements are similar to  standardized education of critical care providers.
                  those guided by PA pressure measurements. 138  Assessment of the  In response to the consensus conference recommendations a
                  dynamic changes in the CVP in response to a fluid bolus or res-  number studies have been completed. Several studies found no
                  piration are more sensitive and specific indices of fluid respon-  improvement or worsening of patient outcomes from PA catheter
                  siveness than absolute CVP or PAOP values.          guided therapy in general, vascular, or cardiothoracic surgical pa-
                     The absolute CVP may be useful in guiding differential diag-  tients. 149–153  The Pulmonary Artery Catheter in the Management
                  nosis. For example, if the PAOP is increased and greater than the  of ICU Patients (PAC-Man) study 154  evaluated  use of a PA
                  CVP, the differential diagnosis should focus on the left heart. If  catheter versus transesophageal echocardiography (TEE) monitor-
                  both the PAOP and CVP are increased, the differential diagnosis  ing in patients with acute respiratory distress syndrome (ARDS),
                  should include diffuse coronary heart disease or cardiomyopathy,  HF, or multiorgan dysfunction. No specific treatment guidelines
                  pericardial constriction or tamponade, or over distention of the  or endpoints were used. There was no significant difference be-
                  right heart. If the CVP is increased and greater than the PAOP,  tween groups in ICU or 28-day mortality; although in the PA
                  consideration should be given to right HF or pulmonary vascular  catheter group, 80% of the patients had treatment changes made
                  disease. 139  In patients with severe HF, CVP   10 mm Hg had a  within 2 hours of catheter insertion. The Sepsis Occurrence in
                  positive predictive value of 85% for a PAOP   22 mm Hg and  Acutely Ill Patients (SOAP) study 155  was an observational study
                  was useful in evaluating 80% of the patients studied. 140  Evalua-  that evaluated the association between PA catheter use and out-
                  tion of left heart function should always include consideration of  come. Although the patients with PA catheters had a higher mor-
                  right heart function. Correct interpretation of the CVP requires  tality rate, when confounding factors such as acuity, age, organ
                  knowledge of the patient’s CO. For example, the treatment would  dysfunction, and comorbidities were controlled for, the use of a
                  be different for a patient with a low CVP and normal CO versus  PA catheter was not associated with increased 60-day mortality.
                  low CO. 141                                         An interesting aspect of the secondary analysis of the SOAP study
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