Page 1092 - Williams Hematology ( PDFDrive )

1066 Part VIII: Monocytes and Macrophages Chapter 67: Structure, Receptors, and Functions of Monocytes and Macrophages 1067

TABLE 67–6. Selected Secretion Products of Macrophages
Proteins Product Comment
Enzymes Lysozyme Bulk product
Urokinase-type plasminogen activator Regulated by inflammation
Collagenase Regulated by inflammation
Elastase Regulated by inflammation
Metalloproteinases Also inhibitors
Complement All components and regulators
Arginase Alternative activation
Angiotensin-converting enzyme Induced glucocorticoids, granulomas
Chitotriosidase Gaucher disease, lysosomal storage
Inhibitors Acid hydrolases All classes (mainly intracellular)
TIMP
Chemokines Many C-C, C-X-C, CX C; e.g., MCP, RANTES, Initiates acute and chronic recruitment of myeloid and
3
IL-8 lymphoid cells
Cytokines IL-1β, TNF-α Pro- and antiinflammatory
IL-6, IL-10, IL-12, IL-17, IL-18, IL-23 Also antagonists, e.g., IL-1Ra
Type I IFN Autocrine and paracrine amplification
Apolipoproteins Apolipoprotein E Local source, marrow origin after adoptive transfer
Growth/differentiation factors TGF-β Also other family members (activins), myeloid growth and
differentiation
M-CSF
GM-CSF
FGF Fibrosis
PDGF Repair
VEGF Angiogenesis
Opsonins Fibronectin, pentraxin (PTX3) Also uncharacterized receptor on Mф
Soluble receptors Mannose receptor Soluble mannose receptor
Cationic peptides Defensins Subpopulations and species variation
Lipids Procoagulant Initiation clotting
Arachidonate metabolites: Pro- and antiinflammatory mediators
Prostaglandins
Leukotrienes
Thromboxanes
Resolvins
Metabolites Reactive oxygen intermediates
Reactive nitrogen intermediates
Haem breakdown (bile pigments)
Iron, B -binding protein
12
Vitamin D metabolites
FGF, fibroblast growth factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; MCP, monocyte che-
motactic protein; M-CSF, macrophage colony-stimulating factor; PDGF, platelet-derived growth factor; RANTES, regulated on activation, normal
T-cell expressed, presumed secreted; TGF, transforming growth factor; TIMP, tissue inhibitor of metalloproteinase; TNF, tumor necrosis factor;
VEGF, vascular endothelial growth factor.
Reproduced with permission from Firestein GS and Kelley WN: Kelley's Textbook of Rheumatology, 8th edition. Philadelphia, PA: Saunders/
Elsevier; 2008.

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