Page 750 - Textbook of Pathology, 6th Edition

734

SECTION III

Systemic Pathology

Figure 24.13 Three forms of endometrial hyperplasias.

glands without cytologic atypia. The stroma is generally hyperplasia by the presence of ‘atypical cells’ in the
dense, cellular and compact (Fig. 24.13,B). hyperplastic epithelium. The extent of cytologic atypia
may be mild, moderate or severe. The cytologic features
The malignant potential of complex hyperplasia in the present in these cells include loss of polarity, large size,
absence of cytologic atypia is 3%. irregular and hyperchromatic nuclei, prominent
nucleoli, and altered nucleocytoplasmic ratio
COMPLEX HYPERPLASIA WITH ATYPIA (COMP-
LEX ATYPICAL HYPERPLASIA). Some authors have (Fig. 24.13,C).
suggested the terms such as endometrial intraepithelial Complex atypical hyperplasia is a precancerous condition
neoplasia (EIN) or carcinoma in situ for this form of and its malignant transformation is related to the degree of
endometrial hyperplasia. Complex hyperplasia with cytologic atypia. About 20-25% cases of untreated atypical
atypia is distinguished from complex non-atypical hyperplasia progress to carcinoma.