Page 742 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

698 SeCTiON iii Rapid Review ` ClassiC labs/FinDinGs Rapid Review ` ClassiC/relevant treatments

lab/DiaGnostiC FinDinG DiaGnosis/Disease PaGe
Pseudopalisading tumor cells on brain biopsy Glioblastoma multiforme 526
Circular grouping of dark tumor cells surrounding pale Homer-Wright rosettes (neuroblastoma, medulloblastoma) 528
neurofibrils
“Waxy” casts with very low urine flow Chronic end-stage renal disease 594
Nodular hyaline deposits in glomeruli Kimmelstiel-Wilson nodules (diabetic nephropathy) 597
Podocyte fusion or “effacement” on electron microscopy Minimal change disease (child with nephrotic syndrome) 597
“Spikes” on basement membrane, “dome-like” Membranous nephropathy (nephrotic syndrome) 597
subepithelial deposits
RBC casts in urine Glomerulonephritis 594
“Tram-track” appearance of capillary loops of glomerular Membranoproliferative glomerulonephritis 596
basement membranes on light microscopy

Anti–glomerular basement membrane antibodies Goodpasture syndrome (glomerulonephritis and 596
hemoptysis)
Cellular crescents in Bowman capsule Rapidly progressive (crescentic) glomerulonephritis 596
“Wire loop” glomerular capillary appearance on light Diffuse proliferative glomerulonephritis (usually seen 596
microscopy with lupus)
Linear appearance of IgG deposition on glomerular and Goodpasture syndrome 596
alveolar basement membranes
“Lumpy bumpy” appearance of glomeruli on Poststreptococcal glomerulonephritis (due to deposition 596
immunofluorescence of IgG, IgM, and C3)
Necrotizing vasculitis (lungs) and necrotizing Granulomatosis with polyangiitis (Wegener; PR3-ANCA/ 596
glomerulonephritis c-ANCA) and Goodpasture syndrome (anti–basement
membrane antibodies)
Thyroid-like appearance of kidney Chronic pyelonephritis (usually due to recurrent 600
infections)
WBC casts in urine Acute pyelonephritis 600
Renal epithelial casts in urine Intrinsic renal failure (eg, ischemia or toxic injury) 601

hCG elevated Choriocarcinoma, hydatidiform mole (occurs with and 633
without embryo, and multiple pregnancy)
Dysplastic squamous cervical cells with “raisinoid” nuclei Koilocytes (HPV: predisposes to cervical cancer) 645
and hyperchromasia
Disarrayed granulosa cells arranged around collections of Call-Exner bodies (granulosa cell tumor of the ovary) 647
eosinophilic fluid
“Chocolate cyst” of ovary Endometriosis (frequently involves both ovaries) 648
Mammary gland (“blue domed”) cyst Fibrocystic change of the breast 649
Glomerulus-like structure surrounding vessel in germ Schiller-Duval bodies (yolk sac tumor) 647
cells

Rectangular, crystal-like, cytoplasmic inclusions in Leydig Reinke crystals (Leydig cell tumor) 653
cells
Thrombi made of white/red layers Lines of Zahn (arterial thrombus, layers of platelets/ 672
RBCs)

Hexagonal, double-pointed, needle-like crystals in Bronchial asthma (Charcot-Leyden crystals: eosinophilic 674
bronchial secretions granules)

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