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80      PART 1: An Overview of the Approach to and Organization of Critical Care



                                  Distribution of high respiratory rate  that increased number of abnormal vital signs was associated with
                      60                                               increased risk of death. Bell and coworkers  recently reported on a
                                                                                                        21
                                                           Control     prospective study in which the vital signs of 1097 patients were assessed
                      50                                   Case        between 9 am and 2 pm over two separate days. They reported that 4.5%
                                                                       of the patients in this study had deranged vital signs that satisfied cri-
                      40                                               teria commonly used to trigger review by a Medical Emergency Team
                                                                       (see below). In these patients, the 30-day mortality was 25% compared
                     Frequency  30      Risk transition                to 3.5% in patients who did not satisfy these criteria. Finally, Buist and
                                                                       coworkers  reported that 8.9% of the 6303 patients admitted over a
                                                                               22
                      20                                               7-month period fulfilled MET criteria, and that this was associated with
                                                                       a 6.8-fold increase in adjusted mortality.
                      10
                                                                       THE OUTCOMES OF CARDIAC ARRESTS ARE POOR
                      0                                                Multiple studies report that the outcome of in-hospital cardiac arrests is
                         12  16  20  24  28  32  36  40  44  48  52
                                                                                                                          23
                                  Respiratory rate (breaths/minute)    poor. Thus, the survival to hospital discharge is typically 10% to 20%,
                                                                       and  many  survivors  are  left  functionally  impaired.  Furthermore,  these
                 FIGURE 12-1.  Differential distribution of respiratory rate in patients who went on to   outcomes have remained largely unchanged for the past 50 years.  In a US
                                                                                                                    24
                 experience a major adverse event (death, cardiac arrest, or ICU admission) within 24 hours   study involving 507 hospitals between January 2000 and February 2007,
                 and age-, sex-, and ward-matched controls. The arrow marks the rate at which more people   there were 86,748 arrests. The overall survival was 18.1%. Importantly,
                 have a significant increase in risk.                  72% of arrests had either asystole or pulseless electrical activity as the ini-
                                                                       tial rhythm,  suggesting that cardiac arrest detection was delayed. When
                                                                                23
                                                                       combined, these findings suggest that in-hospital cardiac arrests are
                                   Distribution of high heart rate     common and are associated with a high mortality and poor neurological
                     50                                                outcome, and that more emphasis should be placed on preventing them.
                                                            Control
                     40                                     Case
                                                                       DETERIORATION OF PATIENTS ON THE FLOOR
                                                                       IS NOT ALWAYS RECOGNIZED
                    Frequency  20 https://kat.cr/user/tahir99/
                     30
                                                                       Although signs of deterioration may be present for several hours prior
                                                      Risk transition
                                                                       to the development of an adverse event, this is not always recognized
                                                                       or acted on by staff on the hospital floor (Figs. 12-4 and 12-5) with an
                                                                       associated increase in patient risk. Studies in three countries reveal that
                     10                                                care was suboptimal prior to the development of an adverse event, 15,19,22
                                                                       suggesting that ward staff may not have the skill set or resources to rec-
                      0                                                ognize, assess, and treat deteriorating patients on the floor.
                             40   60   80   100  120  140   160  180     Additional problems that have been identified include inappropriate
                                     Heart rate (beats/minute)         patient triage,  delayed doctor notification,  failure of the doctor to attend
                                                                                 25
                                                                                                     26
                                                                       and review deteriorating patient, and failure to seek help and advice after
                 FIGURE 12-2.  Differential distribution of heart rate in patients who went on to experi-  review.  In their aggregate, these observations suggest that objective cri-
                                                                            27
                 ence a major adverse event (death, cardiac arrest, or ICU admission) within 24 hours and age-,   teria for deterioration are needed, 27-29  and that when deterioration occurs
                 sex-, and ward-matched controls. The arrow marks the rate at which more people have a   staff with appropriate skills are summoned to assess the patient.
                 significant increase in risk.
                                                                         These observations have important consequences. Studies of treat-
                                                                       ment for myocardial infarction,  sepsis,  severe trauma,  and some
                                                                                               30
                                                                                                                  32
                                                                                                     31
                                                                       forms of ischemic stroke,  all suggest that early intervention in the
                                                                                          33
                               Distribution of low systolic blood pressure  course of deterioration improves outcome.
                     50
                                                            Control
                                                            Case       PRINCIPLES UNDERLYING THE RAPID
                     40                                                RESPONSE TEAM CONCEPT
                    Frequency  30  Risk transition                     A Rapid Response Team (RRT) is a team of clinicians who have expertise
                                                                       in the assessment and treatment of acutely unwell hospitalized patients.
                                                                                                                          34
                                                                       They typically comprise staff from intensive care units. The team is acti-
                                                                       vated in a similar manner to a traditional code team. In contrast, the acti-
                     20
                                                                       vation criteria for an RRT involve degrees of physiological derangement
                                                                       far less pronounced than those that are required to activate a traditional
                     10
                                                                       code team. Thus, code teams are usually activated when a patient has suf-
                                                                       fered a cardiorespiratory arrest as demonstrated by unresponsiveness, no
                      0                                                palpable pulse, and absence of respiratory effort. Activation criteria for an
                        40 50 60 70 80 90 100110 120130 140150 160     RRT typically involve respiratory distress, low blood pressure, tachy- or
                                   Systolic blood pressure (mmHg)
                                                                       bradycardia, and altered conscious state (Table 12-3). Similar to a code
                 FIGURE 12-3.  Differential distribution of heart rate in patients who went on to experi-  team, activation of the RRT can bypass the need to call the parent unit
                 ence a major adverse event (death, cardiac arrest, or ICU admission) within 24 hours and age-,   doctors, although in many hospitals they are often involved in the call.
                 sex-, and ward-matched controls. The arrow marks the rate at which more people have a   Another important principle underlying the concept of the RRT is
                                                                                             35
                 significant increase in risk.                         the response time of the team,  which is typically less than 5 minutes.




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