Page 908 - Hematology_ Basic Principles and Practice ( PDFDrive )

Chapter 56 Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies 791

TABLE Chromosomal Translocations in Ph-Negative Myeloproliferative Neoplasms
56.3
Chromosomal Abnormality Genes Involved MPD Entity
t(9;12)(q34;p13) ETV6-ABL CML-like, T-ALL
5q32 PDGFRB Associated Translocations
t(1;5)(q25;q32) TPM3-PDGFRB Atypical MPN
t(2;5)(p21;q32) SPTBN1-PDGFRB Atypical MPN
t(4;5)(q21;q32) PRKG2-PDGFRB Atypical MPN
t(5;7)(q32;q11) HIP1-PDGFRB CMML-like
t(5;10)(q32;q21) CCDC6-PDGFRB Ph-negative MPN
t(5;12)(q32;p13) ETV6-PDGFRB CEL, CMML
t(5;12)(q32;p13.3) ERC1-PDGFRB Atypical MPN
t(5;14)(q33;q24) NIN-PDGFRB Atypical MPN
t(5;14)(q32;q32) KIA1509-PDGFRB Atypical MPN
t(5;14)(q32;q32) TRIP11-PDGFRB AML
t(5;15)(q23;q15) TP53BP1-PDGFRB CEL
t(5;15)(q32;q22) TPS3BP1-PDGFRB Atypical MPN
t(5;16)(q32;p13) NDE1-PDGFRB Atypical MPN
t(5;17)(q32;p11) HCMOGT1-PDGFRB Juvenile CMML
t(5;17)(q32;p11,2) MYO18A-PDGFRB Atypical MPN
t(5;17)(q32;p13) RABEP1-PDGFRB CMML
t(5;17)(q32;q21) COL1A1-PDGFRB Atypical MPN
8p11 FGFR1 Associated Translocations
t(2;8)(q37;8p11) LRRFIP1-FGFR1 MPN syndrome
t(6;8)(q27;p11) FGFR1OP-FGFR1 Stem cell MPD
t(7;8)(q32;p11) TRIM24-FGFR1 MPN
t(7;8)(q22;p11) CUX1-FGFR1 MPN syndrome
t(8;9)(p11;q22) CEP110-FGFR1 MPN syndrome
t(8;11)(p11;p15) Nup98-FGFR1 MPN syndrome
t(8;12)(p11;p11) FGFR10P-FGFR1 MPN syndrome
t(8;12)(p11;q12) CPSF6-FGFR1 MPN syndrome
t(8;13)(p11;q12) ZMYM2-FGFR1 MPN syndrome, leukemia, lymphoma
t(8;17)(p11;q11) MYO18A-FGFR1 MPN syndrome
t(8;19)(p11;q13) HERVK-FGFR1 MPN syndrome
t(8;22)(p11;q11.2) BCR-FGFR1 Lymphoproliferative disorder
4q12 PDGFRA
del(4)(q12;q12) FIP1L1-PDGFRA CEL
t(4;22)(q12;q11.2) BCR-FGFR1 Atypical CML
4q12 KIT SM
9p24 JAK2
t(9;22)(p24;q11.2) BCR-JAK2 CML-like
t(9;12)(p24;p13) JAK2-ETV6 CML-like
der(9)t(9;12)(p24;q13) JAK-NF-E2 MDS
t(8;9)(p22;p24) PCM1-JAK2 CMPD, AL
der(9;18)t(p13;p11) Not reported PV, PV→MF
der(9;18)(p10;q10) Not reported PV, PV→MF, ET→AML
der(9)t(1;9)(q12;q12) Not reported PV, MF
der(1;7)(q10;p10) Not reported ET
t(12)(q21 or q21) Not reported MF
AL, Acute leukemia; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CEL, chronic eosinophilic leukemia; CML, chronic myelogenous leukemia;
CMML, chronic myelomonocytic leukemia; CMPD, chronic myeloproliferative disorder; ET, essential thrombocytopenia; MF, myelofibrosis; MPD, myeloproliferative
disorder; MPN, myeloproliferative neoplasm; PV, polycythemia vera; SM, systemic mastocytosis.